The Lysosome in Malignant Melanoma: Biology, Function and Therapeutic Applications
Journal
Cells
Journal Volume
11
Journal Issue
9
Date Issued
2022-05-01
Author(s)
Hsu, Chia Hsin
Lee, Keng Jung
Chiu, Yi Han
Huang, Kuo Ching
Wang, Guo Shou
Chen, Lei Po
Liao, Kuang Wen
Abstract
Lysosomes are membrane-bound vesicles that play roles in the degradation and recycling of cellular waste and homeostasis maintenance within cells. False alterations of lysosomal functions can lead to broad detrimental effects and cause various diseases, including cancers. Cancer cells that are rapidly proliferative and invasive are highly dependent on effective lysosomal function. Malignant melanoma is the most lethal form of skin cancer, with high metastasis characteristics, drug resistance, and aggressiveness. It is critical to understand the role of lysosomes in melanoma pathogenesis in order to improve the outcomes of melanoma patients. In this mini-review, we compile our current knowledge of lysosomes’ role in tumorigenesis, progression, therapy resistance, and the current treatment strategies related to lysosomes in melanoma.
Subjects
chemoresistance; lysosome biogenesis; melanoma therapy target
SDGs
Publisher
MDPI
Type
other