https://scholars.lib.ntu.edu.tw/handle/123456789/631039
標題: | The Lysosome in Malignant Melanoma: Biology, Function and Therapeutic Applications | 作者: | Hsu, Chia Hsin Lee, Keng Jung Chiu, Yi Han Huang, Kuo Ching Wang, Guo Shou Chen, Lei Po Liao, Kuang Wen CHEN-SI LIN |
關鍵字: | chemoresistance; lysosome biogenesis; melanoma therapy target | 公開日期: | 1-五月-2022 | 出版社: | MDPI | 卷: | 11 | 期: | 9 | 來源出版物: | Cells | 摘要: | Lysosomes are membrane-bound vesicles that play roles in the degradation and recycling of cellular waste and homeostasis maintenance within cells. False alterations of lysosomal functions can lead to broad detrimental effects and cause various diseases, including cancers. Cancer cells that are rapidly proliferative and invasive are highly dependent on effective lysosomal function. Malignant melanoma is the most lethal form of skin cancer, with high metastasis characteristics, drug resistance, and aggressiveness. It is critical to understand the role of lysosomes in melanoma pathogenesis in order to improve the outcomes of melanoma patients. In this mini-review, we compile our current knowledge of lysosomes’ role in tumorigenesis, progression, therapy resistance, and the current treatment strategies related to lysosomes in melanoma. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129156447&doi=10.3390%2fcells11091492&partnerID=40&md5=d0d6baf85584f084daeeae7f84c52f20 https://scholars.lib.ntu.edu.tw/handle/123456789/631039 |
ISSN: | 2073-4409 | DOI: | 10.3390/cells11091492 |
顯示於: | 獸醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。