Novel terpenoids from the Formosan soft coral Cespitularia hypotentaculata
Journal
Journal of Natural Products
Journal Volume
65
Journal Issue
10
Pages
1429-1433
Date Issued
2002
Author(s)
Abstract
Four new cytotoxic diterpenes, cespitularins A-D (1-4), having the verticillane skeleton, a new cytotoxic norditerpene, cesputularin E (5), that possesses a novel norverticillane skeleton, and three new diterpenes, cespitularins F-H (6-8), possessing a novel carbon skeleton named cespitularane, were isolated from the methylene chloride solubles of the Formosan soft coral Cespitularia hypotentaculata. The structures of cespitularins A-H (1-8) were elucidated by 1D and 2D NMR spectral-analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Other Subjects
cespitularin a; cespitularin b; cespitularin c; cespitularin d; diterpene; terpenoid; unclassified drug; article; carbon nuclear magnetic resonance; coral; cytotoxicity; drug isolation; fractionation; leukemia cell; structure analysis; Animals; Anthozoa; Antineoplastic Agents; Diterpenes; Drug Screening Assays, Antitumor; Molecular Structure; Spectrum Analysis; Tumor Cells, Cultured; Alcyonacea; Anthozoa
Type
journal article