Chronic hepatitis B virus infection and dyslipidemia
Journal
Journal of the Formosan Medical Association
Journal Volume
103
Journal Issue
4
Pages
286-291
Date Issued
2004
Author(s)
Abstract
Background and Purpose: The association of chronic hepatitis B virus (HBV) infection and decreased levels of high-density lipoprotein cholesterol (HDL-C) has been well documented. However, the relationship between dyslipidemia and asymptomatic chronic HBV infection is still unclear. Methods: In 1997, 1330 medical center employees (405 men and 925 women) were recruited to evaluate the effects of chronic HBV infection on serum lipid profile, including total cholesterol (TC), HDL-C, low-density lipoprotein cholesterol, and triglycerides (TG). Among these patients, 195 were found to have chronic HBV infection and 35 (17.9%) of them were found to have elevated alanine aminotransferase (ALT). Multiple Linear regression analyses were used to evaluate the effects of chronic HBV infection on serum lipids. Results: The most significant finding was that levels of TC and HDL-C were decreased by 5.8 and 2.7 mg/dL respectively, among patients with asymptomatic chronic HBV infection (serums ALT < 40 U/L). After controlling for other determinants, male gender, old age, higher body mass index (BMI) and waist-to-hip ratio, current smoking, and hepatitis B surface antigen-negative status with ALT ? 40 U/L were associated with lower serum HDL-C and higher TG levels. However, moderate to heavy alcohol drinking, physically active lifestyle, and lower BMI were associated with higher levels of HDL-C. Conclusions: Asymptomatic chronic HBV infection was associated with lower levels of TC and HDL-C Elevation of ALT was also an indicator of lower levels of HDL-C in patients with chronic hepatitis B and lower serum HDL-C and higher TG levels in patients without HBV infection. These findings also indicated the need to monitor the risk of atherosclerotic disease in patients with asymptomatic chronic HBV infection, especially those with lower HDL-C levels.
Subjects
Alanine aminotransferase; Dyslipidemia; Hepatitis B virus; Lipoprotein, HDL cholesterol
SDGs
Other Subjects
alanine aminotransferase; cholesterol; hepatitis B surface antigen; high density lipoprotein cholesterol; lipid; low density lipoprotein cholesterol; triacylglycerol; alanine aminotransferase; adult; age; aged; alcohol consumption; anthropometry; article; atherosclerosis; body mass; cigarette smoking; controlled study; disease association; dyslipidemia; female; health care personnel; hepatitis B; Hepatitis B virus; human; lifestyle; linear regression analysis; major clinical study; male; patient monitoring; physical activity; risk assessment; sex difference; symptom; blood; hepatitis B; hyperlipidemia; middle aged; Adult; Aged; Alanine Transaminase; Female; Hepatitis B, Chronic; Humans; Hyperlipidemias; Male; Middle Aged
Type
journal article
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