https://scholars.lib.ntu.edu.tw/handle/123456789/514909
標題: | Chronic hepatitis B virus infection and dyslipidemia | 作者: | TA-CHEN SU Lee Y.-T. Cheng T.-J. Chien H.-P. Wang J.-D. |
關鍵字: | Alanine aminotransferase; Dyslipidemia; Hepatitis B virus; Lipoprotein, HDL cholesterol | 公開日期: | 2004 | 卷: | 103 | 期: | 4 | 起(迄)頁: | 286-291 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background and Purpose: The association of chronic hepatitis B virus (HBV) infection and decreased levels of high-density lipoprotein cholesterol (HDL-C) has been well documented. However, the relationship between dyslipidemia and asymptomatic chronic HBV infection is still unclear. Methods: In 1997, 1330 medical center employees (405 men and 925 women) were recruited to evaluate the effects of chronic HBV infection on serum lipid profile, including total cholesterol (TC), HDL-C, low-density lipoprotein cholesterol, and triglycerides (TG). Among these patients, 195 were found to have chronic HBV infection and 35 (17.9%) of them were found to have elevated alanine aminotransferase (ALT). Multiple Linear regression analyses were used to evaluate the effects of chronic HBV infection on serum lipids. Results: The most significant finding was that levels of TC and HDL-C were decreased by 5.8 and 2.7 mg/dL respectively, among patients with asymptomatic chronic HBV infection (serums ALT < 40 U/L). After controlling for other determinants, male gender, old age, higher body mass index (BMI) and waist-to-hip ratio, current smoking, and hepatitis B surface antigen-negative status with ALT ? 40 U/L were associated with lower serum HDL-C and higher TG levels. However, moderate to heavy alcohol drinking, physically active lifestyle, and lower BMI were associated with higher levels of HDL-C. Conclusions: Asymptomatic chronic HBV infection was associated with lower levels of TC and HDL-C Elevation of ALT was also an indicator of lower levels of HDL-C in patients with chronic hepatitis B and lower serum HDL-C and higher TG levels in patients without HBV infection. These findings also indicated the need to monitor the risk of atherosclerotic disease in patients with asymptomatic chronic HBV infection, especially those with lower HDL-C levels. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-3342994350&partnerID=40&md5=7e9bedfda8dd3a4eda720efd982f487a https://scholars.lib.ntu.edu.tw/handle/123456789/514909 |
ISSN: | 0929-6646 | SDG/關鍵字: | alanine aminotransferase; cholesterol; hepatitis B surface antigen; high density lipoprotein cholesterol; lipid; low density lipoprotein cholesterol; triacylglycerol; alanine aminotransferase; adult; age; aged; alcohol consumption; anthropometry; article; atherosclerosis; body mass; cigarette smoking; controlled study; disease association; dyslipidemia; female; health care personnel; hepatitis B; Hepatitis B virus; human; lifestyle; linear regression analysis; major clinical study; male; patient monitoring; physical activity; risk assessment; sex difference; symptom; blood; hepatitis B; hyperlipidemia; middle aged; Adult; Aged; Alanine Transaminase; Female; Hepatitis B, Chronic; Humans; Hyperlipidemias; Male; Middle Aged |
顯示於: | 醫學系 |
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