心室輔助器在心衰竭動物模型利用微流體通道上離子運動特性的研究及其相關之應用

As the use of ventricular assist device
(VAD) has increased dramatically during the
past decade, it is necessary to understand the
hemodynamic change and interaction
between VAD and physiological ionic signal
transmission. The improvement for Taita
No.1 VAD was still persist no matter the
preparation of polyurethane, endothelial cell
culture prevent thrombosis, newer streamline
of impeller design, the biocontroller
development that matches physiological
requirement, and spectrum analysis of flow
and pressure. All things have to make
additional efforts. Because physiological
signal changes will happen when patients are
under VAD-treatment, ion movement versus
expressions of neural signal transmissions
becomes extremely important. By selecting a
point of view in engineering to discuss
physical mechanisms occurred in ion
movement that is much helpful in clinical
diagnosis and the following therapeutic
development. We introduce the basic
knowledge of a neuron in the following
sections to illustrate that why we are interest
in physical mechanisms in ion movements
and we also try to solve the problem
according to some models as far as we know.
Though the signal transmitted of neuron of
different types has sizable differences, the
form of signals are basically the same, all
consist of change of the electric potential on
the cell membrane of neuron. The electric
potential perturbation produced by a part of
cells will be spread to the surrounding area
gradually, and then finished the information
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transmission. Unless the signal amplification
caused of energy supplement acquired by
neuron, with the increase with the distance
among the signal sources and neuron, the
perturbation will gradually weaken.