A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins
Journal
American Journal of Hypertension
Journal Volume
16
Journal Issue
2
Pages
158-162
Date Issued
2003
Author(s)
Ranade K.
Hinds D.
Hsiung C.A.
Chang M.-S.
Chen Y.-T.
Pesich R.
Hebert J.
Chen Y.-D.I.
Dzau V.
Olshen R.
Curb D.
Botstein D.
Cox D.R.
Risch N.
Abstract
Background: Our understanding of genes that predispose to essential hypertension is poor. Methods: A genome-wide scan for linkage at ?10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580). Results: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5. Conclusions: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population. ? 2003 American Journal of Hypertension, Ltd.
SDGs
Other Subjects
adult; article; Chinese; chromosome 10p; controlled study; female; gene frequency; gene locus; genetic susceptibility; genotype; human; hypertension; Japan; major clinical study; male; priority journal; Adult; Asian Continental Ancestry Group; China; Chromosome Mapping; Chromosomes, Human, Pair 10; Genetic Predisposition to Disease; Genome, Human; Humans; Hypertension; Japan; Lod Score; Middle Aged
Type
journal article