https://scholars.lib.ntu.edu.tw/handle/123456789/495512
標題: | A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins | 作者: | Ranade K. Hinds D. Hsiung C.A. LEE-MING CHUANG Chang M.-S. Chen Y.-T. Pesich R. Hebert J. Chen Y.-D.I. Dzau V. Olshen R. Curb D. Botstein D. Cox D.R. Risch N. |
公開日期: | 2003 | 卷: | 16 | 期: | 2 | 起(迄)頁: | 158-162 | 來源出版物: | American Journal of Hypertension | 摘要: | Background: Our understanding of genes that predispose to essential hypertension is poor. Methods: A genome-wide scan for linkage at ?10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580). Results: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5. Conclusions: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population. ? 2003 American Journal of Hypertension, Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-12244276719&doi=10.1016%2fS0895-7061%2802%2903245-4&partnerID=40&md5=f9ed6d264e3900a014aa0baaf5e7d3dd https://scholars.lib.ntu.edu.tw/handle/123456789/495512 |
ISSN: | 0895-7061 | DOI: | 10.1016/S0895-7061(02)03245-4 | SDG/關鍵字: | adult; article; Chinese; chromosome 10p; controlled study; female; gene frequency; gene locus; genetic susceptibility; genotype; human; hypertension; Japan; major clinical study; male; priority journal; Adult; Asian Continental Ancestry Group; China; Chromosome Mapping; Chromosomes, Human, Pair 10; Genetic Predisposition to Disease; Genome, Human; Humans; Hypertension; Japan; Lod Score; Middle Aged |
顯示於: | 醫學系 |
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