Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation
Journal
Blood
Journal Volume
115
Journal Issue
14
Pages
2749-2754
Date Issued
2010
Author(s)
Huang Y.-N.
Chang Y.-.
Lee F.-Y.
Liu M.-C.
Liu C.-W.
Tseng M.-H.
Huang C.-F.
Abstract
Mutations of nicotinamide adenine dinucleotide phosphate-dependent isocitrate dehydrogenase gene (IDH1) have been identified in patients with gliomas. Recent genome-wide screening also revealed IDH1 mutation as a recurrent event in acute myeloid leukemia (AML), but its clinical implications in AML are largely unknown. We analyzed 493 adult Chinese AML patients in Taiwan and found 27 patients (5.5%) harboring this mutation. IDH1 mutation was strongly associated with normal karyotype (8.4%, P = .002), isolated monosomy 8 (P = .043), NPM1 mutation (P < .001), and French-American-British M1 subtype (P < .001), but inversely associated with French-American-British M4 subtype (P = .030) and expression of HLA-DR, CD13, and CD14 (P = .002, .003, and .038, respectively). There was no impact of this mutation on patient survival. Sequential analysis of IDH1 mutation was performed in 130 patients during follow-ups. None of the 112 patients without IDH1 mutation at diagnosis acquired this mutation at relapse. In all 18 IDH1-mutated patients studied, the mutation disappeared in complete remission; the same mutation re-appeared in all 11 samples obtained at relapse. We conclude that IDH1 is associated with distinct clinical and biologic characteristics and seems to be very stable during disease evolution. ? 2010 by The American Society of Hematology.
SDGs
Other Subjects
CD14 antigen; HLA DR antigen; isocitrate dehydrogenase; microsomal aminopeptidase; nucleophosmin; acute granulocytic leukemia; adult; aged; article; disease association; disease course; female; follow up; gene mutation; human; karyotype; major clinical study; male; monosomy; priority journal; protein expression; relapse; remission; survival rate; Taiwan
Type
journal article