https://scholars.lib.ntu.edu.tw/handle/123456789/537478
標題: | Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation | 作者: | WEN-CHIEN CHOU HSIN-AN HOU Chen, Chien-Yuan JIH-LUH TANG MING YAO WOEI TSAY BOR-SHENG KO SHANG-JU WU SHANG-YI HUANG SZU-CHUN HSU YAO-CHANG CHEN Huang Y.-N. Chang Y.-. Lee F.-Y. Liu M.-C. Liu C.-W. Tseng M.-H. Huang C.-F. HWEI-FANG TIEN |
公開日期: | 2010 | 卷: | 115 | 期: | 14 | 起(迄)頁: | 2749-2754 | 來源出版物: | Blood | 摘要: | Mutations of nicotinamide adenine dinucleotide phosphate-dependent isocitrate dehydrogenase gene (IDH1) have been identified in patients with gliomas. Recent genome-wide screening also revealed IDH1 mutation as a recurrent event in acute myeloid leukemia (AML), but its clinical implications in AML are largely unknown. We analyzed 493 adult Chinese AML patients in Taiwan and found 27 patients (5.5%) harboring this mutation. IDH1 mutation was strongly associated with normal karyotype (8.4%, P = .002), isolated monosomy 8 (P = .043), NPM1 mutation (P < .001), and French-American-British M1 subtype (P < .001), but inversely associated with French-American-British M4 subtype (P = .030) and expression of HLA-DR, CD13, and CD14 (P = .002, .003, and .038, respectively). There was no impact of this mutation on patient survival. Sequential analysis of IDH1 mutation was performed in 130 patients during follow-ups. None of the 112 patients without IDH1 mutation at diagnosis acquired this mutation at relapse. In all 18 IDH1-mutated patients studied, the mutation disappeared in complete remission; the same mutation re-appeared in all 11 samples obtained at relapse. We conclude that IDH1 is associated with distinct clinical and biologic characteristics and seems to be very stable during disease evolution. ? 2010 by The American Society of Hematology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77950968519&doi=10.1182%2fblood-2009-11-253070&partnerID=40&md5=70b4f59525a131e298c47698a3b09cce https://scholars.lib.ntu.edu.tw/handle/123456789/537478 |
ISSN: | 0006-4971 | DOI: | 10.1182/blood-2009-11-253070 | SDG/關鍵字: | CD14 antigen; HLA DR antigen; isocitrate dehydrogenase; microsomal aminopeptidase; nucleophosmin; acute granulocytic leukemia; adult; aged; article; disease association; disease course; female; follow up; gene mutation; human; karyotype; major clinical study; male; monosomy; priority journal; protein expression; relapse; remission; survival rate; Taiwan |
顯示於: | 醫學系 |
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