Envelope gene sequences of human T-lymphotropic virus type I in Taiwan
Journal
Archives of Virology
Journal Volume
141
Journal Issue
2
Pages
219-229
Date Issued
1996
Author(s)
Abstract
Three major types of HTLV-I had been proposed, the Melanesian type, the Zairian type, and the cosmopolitan type, which was further divided into subtypes A, B and C, according to the phylogenetic tree constructed from LTR sequences of current HLTV-I isolates. In this study, the envelope gene sequences of HTLV-I from 9 Taiwanese were analyzed. Based on the phylogenetic tree constructed by unweighed pair group method and the sequence homology analysis by GCG computer programs, the envelope gene sequences of HTLV-I proviruses from these 9 Taiwanese belonged to subtype A or subtype B of the cosmopolitan type and were closely related to HTLV-I from Japan. Twelve subtype-specific nucleotide variations were deduced from the comparison of complete or partial envelope gene sequences of 16 HTLV-I isolates of known subtypes as well as those of 9 Taiwanese. These data provided the basis for subtyping the cosmopolitan type of HTLV-I by amplification of envelope gene sequences and restriction fragment length polymorphism studies. A more extensive survey based upon this proposal was warranted. ? Springer-Verlag 1996.
SDGs
Other Subjects
primer DNA; virus DNA; article; chemistry; classification; computer program; envelope gene; genetic variability; genetics; human; Human T cell leukemia virus 1; Human T cell leukemia virus infection; isolation and purification; Japan; molecular genetics; nucleotide sequence; phylogeny; polymerase chain reaction; prevalence; sequence homology; Taiwan; Base Sequence; DNA Primers; DNA, Viral; Genes, env; HTLV-I Infections; Human T-lymphotropic virus 1; Humans; Japan; Molecular Sequence Data; Phylogeny; Polymerase Chain Reaction; Prevalence; Sequence Homology, Nucleic Acid; Software; Taiwan; Variation (Genetics); Human immunodeficiency virus; Human T-lymphotropic virus 1
Type
journal article