https://scholars.lib.ntu.edu.tw/handle/123456789/503700
標題: | Envelope gene sequences of human T-lymphotropic virus type I in Taiwan | 作者: | Lin M.T. Chen Y.C. PEI-JER CHEN YA-CHIEN YANG JIH-LUH TANG Wu J.M. Chuang S.E. Yang C.S. |
公開日期: | 1996 | 卷: | 141 | 期: | 2 | 起(迄)頁: | 219-229 | 來源出版物: | Archives of Virology | 摘要: | Three major types of HTLV-I had been proposed, the Melanesian type, the Zairian type, and the cosmopolitan type, which was further divided into subtypes A, B and C, according to the phylogenetic tree constructed from LTR sequences of current HLTV-I isolates. In this study, the envelope gene sequences of HTLV-I from 9 Taiwanese were analyzed. Based on the phylogenetic tree constructed by unweighed pair group method and the sequence homology analysis by GCG computer programs, the envelope gene sequences of HTLV-I proviruses from these 9 Taiwanese belonged to subtype A or subtype B of the cosmopolitan type and were closely related to HTLV-I from Japan. Twelve subtype-specific nucleotide variations were deduced from the comparison of complete or partial envelope gene sequences of 16 HTLV-I isolates of known subtypes as well as those of 9 Taiwanese. These data provided the basis for subtyping the cosmopolitan type of HTLV-I by amplification of envelope gene sequences and restriction fragment length polymorphism studies. A more extensive survey based upon this proposal was warranted. ? Springer-Verlag 1996. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/503700 | ISSN: | 0304-8608 | DOI: | 10.1007/BF01718395 | SDG/關鍵字: | primer DNA; virus DNA; article; chemistry; classification; computer program; envelope gene; genetic variability; genetics; human; Human T cell leukemia virus 1; Human T cell leukemia virus infection; isolation and purification; Japan; molecular genetics; nucleotide sequence; phylogeny; polymerase chain reaction; prevalence; sequence homology; Taiwan; Base Sequence; DNA Primers; DNA, Viral; Genes, env; HTLV-I Infections; Human T-lymphotropic virus 1; Humans; Japan; Molecular Sequence Data; Phylogeny; Polymerase Chain Reaction; Prevalence; Sequence Homology, Nucleic Acid; Software; Taiwan; Variation (Genetics); Human immunodeficiency virus; Human T-lymphotropic virus 1 |
顯示於: | 醫學檢驗暨生物技術學系 |
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