A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancer
Journal
The Prostate
Date Issued
2024-02-20
Author(s)
Ye, Pei-Chen
Leu, Wohn-Jenn
Yeh, Tsung-Yu
Hsu, Yu-Tung
Lin, Yi-Chin
Wei, Zi-Yuan
Chen, Yi-Chin
Chiang, Yi-Chang
Hsu, Jui-Ling
Chan, She-Hung
Abstract
Metastatic castration-resistant prostate cancer (CRPC), the most refractory prostate cancer, inevitably progresses and becomes unresponsive to hormone therapy, revealing a pressing unmet need for this disease. Novel agents targeting HDAC6 and microtubule dynamics can be a potential anti-CRPC strategy.
Subjects
DNA damage repair; HDAC6 inhibitors; castration-resistant prostate cancer; cisplatin; spindle assembly checkpoint
SDGs
Type
journal article