https://scholars.lib.ntu.edu.tw/handle/123456789/641117
標題: | A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancer | 作者: | Ye, Pei-Chen Leu, Wohn-Jenn Yeh, Tsung-Yu Hsu, Yu-Tung Lin, Yi-Chin Wei, Zi-Yuan Chen, Yi-Chin Chiang, Yi-Chang Hsu, Jui-Ling Chan, She-Hung LIH-CHING HSU JI-WANG CHERN CHAO-WU YU JIH-HWA GUH |
關鍵字: | DNA damage repair; HDAC6 inhibitors; castration-resistant prostate cancer; cisplatin; spindle assembly checkpoint | 公開日期: | 20-二月-2024 | 來源出版物: | The Prostate | 摘要: | Metastatic castration-resistant prostate cancer (CRPC), the most refractory prostate cancer, inevitably progresses and becomes unresponsive to hormone therapy, revealing a pressing unmet need for this disease. Novel agents targeting HDAC6 and microtubule dynamics can be a potential anti-CRPC strategy. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/641117 | ISSN: | 02704137 | DOI: | 10.1002/pros.24678 |
顯示於: | 藥學系 |
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