Bioactive cembranoids from the soft coral Sinularia crassa
Journal
Marine Drugs
Journal Volume
9
Journal Issue
10
Pages
1955-1968
Date Issued
2011
Author(s)
Abstract
Eight new cembranoids, crassarines A-H (1-8) were isolated from the Formosan soft coral Sinularia crassa. Compounds 1-3 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids. The absolute configuration of 6 was determined using the Mosher's method. Compounds 6 and 8 were found to significantly inhibit the expression of both pro-inflammatory iNOS and COX-2 proteins at 10 μM, respectively, while compounds 4-8 were found to be non-cytotoxic toward the selected human liver cancer cells. ? 2011 by the authors; licensee MDPI.
Subjects
Anti-inflammatory; Crassarines A-H; Sinularia crassa
SDGs
Other Subjects
cembranoid; crassarine A; crassarine B; crassarine C; crassarine D; crassarine E; crassarine F; crassarine G; crassarine H; cyclooxygenase 2; inducible nitric oxide synthase; unclassified drug; animal cell; antiinflammatory activity; article; cancer cell; concentration response; controlled study; coral; drug cytotoxicity; drug isolation; drug structure; human; human cell; liver cancer; nonhuman; protein expression; Sinularia crassa; Taiwan; Alcyonacea; Sinularia
Type
journal article