https://scholars.lib.ntu.edu.tw/handle/123456789/363593
標題: | Bioactive cembranoids from the soft coral Sinularia crassa | 作者: | Chao, C.-H. Chou, K.-J. Huang, C.-Y. Wen, Z.-H. Hsu, C.-H. Wu, Y.-C. CHANG-FENG DAI Sheu, J.-H. |
關鍵字: | Anti-inflammatory; Crassarines A-H; Sinularia crassa | 公開日期: | 2011 | 卷: | 9 | 期: | 10 | 起(迄)頁: | 1955-1968 | 來源出版物: | Marine Drugs | 摘要: | Eight new cembranoids, crassarines A-H (1-8) were isolated from the Formosan soft coral Sinularia crassa. Compounds 1-3 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids. The absolute configuration of 6 was determined using the Mosher's method. Compounds 6 and 8 were found to significantly inhibit the expression of both pro-inflammatory iNOS and COX-2 proteins at 10 μM, respectively, while compounds 4-8 were found to be non-cytotoxic toward the selected human liver cancer cells. ? 2011 by the authors; licensee MDPI. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-80054891417&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/363593 |
DOI: | 10.3390/md9101955 | SDG/關鍵字: | cembranoid; crassarine A; crassarine B; crassarine C; crassarine D; crassarine E; crassarine F; crassarine G; crassarine H; cyclooxygenase 2; inducible nitric oxide synthase; unclassified drug; animal cell; antiinflammatory activity; article; cancer cell; concentration response; controlled study; coral; drug cytotoxicity; drug isolation; drug structure; human; human cell; liver cancer; nonhuman; protein expression; Sinularia crassa; Taiwan; Alcyonacea; Sinularia |
顯示於: | 海洋研究所 |
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