Striatal dopamine transporter binding for predicting the development of delayed neuropsychological sequelae in suicide attempters by carbon monoxide poisoning: A SPECT study
Journal
Psychiatry Research - Neuroimaging
Journal Volume
194
Journal Issue
3
Pages
219-223
Date Issued
2011
Author(s)
Yang K.-C.
Ku H.-L.
Wu C.-L.
Wang S.-J.
Yang C.-C.
Deng J.-F.
MING-BEEN LEE
Chou Y.-H.
Abstract
Carbon monoxide poisoning (COP) after charcoal burning results in delayed neuropsychological sequelae (DNS), which show clinical resemblance to Parkinson's disease, without adequate predictors at present. This study examined the role of dopamine transporter (DAT) binding for the prediction of DNS. Twenty-seven suicide attempters with COP were recruited. Seven of them developed DNS, while the remainder did not. The striatal DAT binding was measured by single photon emission computed tomography with 99mTc-TRODAT. The specific uptake ratio was derived based on a ratio equilibrium model. Using a logistic regression model, multiple clinical variables were examined as potential predictors for DNS. COP patients with DNS had a lower binding on left striatal DAT binding than patients without DNS. Logistic regression analysis showed that a combination of initial loss of consciousness and lower left striatal DAT binding predicted the development of DNS. Our data indicate that the left striatal DAT binding could help to predict the development of DNS. This finding not only demonstrates the feasibility of brain imaging techniques for predicting the development of DNS but will also help clinicians to improve the quality of care for COP patients. ? 2011 Elsevier Ireland Ltd.
Subjects
99mTc-TRODAT; Carbon monoxide poisoning (COP); Delayed neuropsychological sequelae (DNS); Dopamine transporter (DAT); Single photon emission computed tomography (SPECT); Suicide
SDGs
Other Subjects
[2 [[2 [[[3 (4 chlorophenyl) 8 methyl 8 azabicyclo[3.2.1]oct 2 yl]methyl](2 mercaptoethyl)amino]ethyl]amino]ethanethiolato]oxotechnetium tc 99m; dopamine transporter; adult; article; carbon monoxide intoxication; clinical article; delayed neuropsychological sequelae; feasibility study; female; human; male; neuroimaging; neuropsychology; patient care; predictor variable; priority journal; protein binding; single photon emission computer tomography; suicide attempt; unconsciousness; Adolescent; Adult; Carbon Monoxide Poisoning; Cognition Disorders; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Logistic Models; Male; Mental Status Schedule; Neuropsychological Tests; Organotechnetium Compounds; Protein Binding; Radiopharmaceuticals; Suicide, Attempted; Tomography, Emission-Computed, Single-Photon; Tropanes; Young Adult
Type
journal article