https://scholars.lib.ntu.edu.tw/handle/123456789/585766
標題: | Striatal dopamine transporter binding for predicting the development of delayed neuropsychological sequelae in suicide attempters by carbon monoxide poisoning: A SPECT study | 作者: | Yang K.-C. Ku H.-L. Wu C.-L. Wang S.-J. Yang C.-C. Deng J.-F. MING-BEEN LEE Chou Y.-H. |
關鍵字: | 99mTc-TRODAT; Carbon monoxide poisoning (COP); Delayed neuropsychological sequelae (DNS); Dopamine transporter (DAT); Single photon emission computed tomography (SPECT); Suicide | 公開日期: | 2011 | 卷: | 194 | 期: | 3 | 起(迄)頁: | 219-223 | 來源出版物: | Psychiatry Research - Neuroimaging | 摘要: | Carbon monoxide poisoning (COP) after charcoal burning results in delayed neuropsychological sequelae (DNS), which show clinical resemblance to Parkinson's disease, without adequate predictors at present. This study examined the role of dopamine transporter (DAT) binding for the prediction of DNS. Twenty-seven suicide attempters with COP were recruited. Seven of them developed DNS, while the remainder did not. The striatal DAT binding was measured by single photon emission computed tomography with 99mTc-TRODAT. The specific uptake ratio was derived based on a ratio equilibrium model. Using a logistic regression model, multiple clinical variables were examined as potential predictors for DNS. COP patients with DNS had a lower binding on left striatal DAT binding than patients without DNS. Logistic regression analysis showed that a combination of initial loss of consciousness and lower left striatal DAT binding predicted the development of DNS. Our data indicate that the left striatal DAT binding could help to predict the development of DNS. This finding not only demonstrates the feasibility of brain imaging techniques for predicting the development of DNS but will also help clinicians to improve the quality of care for COP patients. ? 2011 Elsevier Ireland Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-82455199297&doi=10.1016%2fj.pscychresns.2011.04.006&partnerID=40&md5=02e3e38a39d93f137a6dc499b5e08536 https://scholars.lib.ntu.edu.tw/handle/123456789/585766 |
ISSN: | 9254927 | DOI: | 10.1016/j.pscychresns.2011.04.006 | SDG/關鍵字: | [2 [[2 [[[3 (4 chlorophenyl) 8 methyl 8 azabicyclo[3.2.1]oct 2 yl]methyl](2 mercaptoethyl)amino]ethyl]amino]ethanethiolato]oxotechnetium tc 99m; dopamine transporter; adult; article; carbon monoxide intoxication; clinical article; delayed neuropsychological sequelae; feasibility study; female; human; male; neuroimaging; neuropsychology; patient care; predictor variable; priority journal; protein binding; single photon emission computer tomography; suicide attempt; unconsciousness; Adolescent; Adult; Carbon Monoxide Poisoning; Cognition Disorders; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Logistic Models; Male; Mental Status Schedule; Neuropsychological Tests; Organotechnetium Compounds; Protein Binding; Radiopharmaceuticals; Suicide, Attempted; Tomography, Emission-Computed, Single-Photon; Tropanes; Young Adult |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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