Associations of human leukocyte antigen class II genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk
Journal
Cancer
Journal Volume
118
Journal Issue
1
Pages
223-231
Date Issued
2012
Author(s)
Chuang L.-C.
Chen H.-C.
Lin P.-J.
Lee B.
Lin C.-Y.
Pan M.-H.
You S.-L.
Chen C.-J.
Abstract
BACKGROUND: Only a small proportion of women infected with human papillomavirus type 18 (HPV18) may progress to persistent infection and cervical neoplasia. This community-based cohort study aimed to assess associations with human leukocyte antigen (HLA) class II genotypes for natural infection of HPV18 and subsequent risk of cervical neoplasia. METHODS: Among 10,190 cytologically normal participants, 125 with HPV18 infection were identified by HPV blot kit. HPV18 viral load at study entry was examined by real-time polymerase chain reaction; persistent infection was defined as HPV18 infection at 2 consecutive examinations. RESULTS: There was a significant association between HLA-DRB1*0403 allele and high HPV18 viral load (>1000 copies in 50 ng of total DNA) at study entry (odds ratio [OR], 7.2; 95% confidence interval [CI], 2.0-25.2). After adjustment for age and viral load at study entry, haplotype HLA-DRB1*0405-DQA1*0301-DQB1*0302 was significantly associated with persistent HPV18 infection (OR, 13.3; 95% CI, 1.7-105.9). HLA-DRB1*0403 allele was also associated with a significantly increased risk of high-grade squamous intraepithelial lesion or cancer, showing a multivariate-adjusted hazard ratio (95% CI) of 18.1 (2.6-128.5). CONCLUSIONS: HLA-DRB1*0403 allele and HLA-DRB1*0405-DQA1*0301- DQB1*0302 haplotype may play important roles in determination of high viral load and persistent infection of HPV18 and subsequent cervical neoplasia risk. Copyright ? 2011 American Cancer Society.
SDGs
Other Subjects
HLA antigen class 2; HLA DQA1 antigen; HLA DQB1 antigen; HLA DRB1 antigen; adult; aged; allele; article; cancer grading; cancer risk; cohort analysis; community; controlled study; female; follow up; genetic association; genetic polymorphism; genotype; haplotype; human; Human papillomavirus type 18; major clinical study; nonhuman; papillomavirus infection; priority journal; real time polymerase chain reaction; uterine cervix carcinoma in situ; virus load; Cervical Intraepithelial Neoplasia; Cohort Studies; Female; Genotype; Histocompatibility Antigens Class II; HLA Antigens; Human papillomavirus 18; Humans; Middle Aged; Papillomavirus Infections; Risk Factors; Viral Load
Type
journal article