https://scholars.lib.ntu.edu.tw/handle/123456789/522638
標題: | Associations of human leukocyte antigen class II genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk | 作者: | Chuang L.-C. CHUNG-YI HU Chen H.-C. Lin P.-J. Lee B. Lin C.-Y. Pan M.-H. You S.-L. CHANG-YAO HSIEH Chen C.-J. |
公開日期: | 2012 | 卷: | 118 | 期: | 1 | 起(迄)頁: | 223-231 | 來源出版物: | Cancer | 摘要: | BACKGROUND: Only a small proportion of women infected with human papillomavirus type 18 (HPV18) may progress to persistent infection and cervical neoplasia. This community-based cohort study aimed to assess associations with human leukocyte antigen (HLA) class II genotypes for natural infection of HPV18 and subsequent risk of cervical neoplasia. METHODS: Among 10,190 cytologically normal participants, 125 with HPV18 infection were identified by HPV blot kit. HPV18 viral load at study entry was examined by real-time polymerase chain reaction; persistent infection was defined as HPV18 infection at 2 consecutive examinations. RESULTS: There was a significant association between HLA-DRB1*0403 allele and high HPV18 viral load (>1000 copies in 50 ng of total DNA) at study entry (odds ratio [OR], 7.2; 95% confidence interval [CI], 2.0-25.2). After adjustment for age and viral load at study entry, haplotype HLA-DRB1*0405-DQA1*0301-DQB1*0302 was significantly associated with persistent HPV18 infection (OR, 13.3; 95% CI, 1.7-105.9). HLA-DRB1*0403 allele was also associated with a significantly increased risk of high-grade squamous intraepithelial lesion or cancer, showing a multivariate-adjusted hazard ratio (95% CI) of 18.1 (2.6-128.5). CONCLUSIONS: HLA-DRB1*0403 allele and HLA-DRB1*0405-DQA1*0301- DQB1*0302 haplotype may play important roles in determination of high viral load and persistent infection of HPV18 and subsequent cervical neoplasia risk. Copyright ? 2011 American Cancer Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-83855162910&doi=10.1002%2fcncr.26227&partnerID=40&md5=95b4e2ed923e47e938540b4b687fe098 https://scholars.lib.ntu.edu.tw/handle/123456789/522638 |
ISSN: | 0008-543X | DOI: | 10.1002/cncr.26227 | SDG/關鍵字: | HLA antigen class 2; HLA DQA1 antigen; HLA DQB1 antigen; HLA DRB1 antigen; adult; aged; allele; article; cancer grading; cancer risk; cohort analysis; community; controlled study; female; follow up; genetic association; genetic polymorphism; genotype; haplotype; human; Human papillomavirus type 18; major clinical study; nonhuman; papillomavirus infection; priority journal; real time polymerase chain reaction; uterine cervix carcinoma in situ; virus load; Cervical Intraepithelial Neoplasia; Cohort Studies; Female; Genotype; Histocompatibility Antigens Class II; HLA Antigens; Human papillomavirus 18; Humans; Middle Aged; Papillomavirus Infections; Risk Factors; Viral Load |
顯示於: | 醫學系 |
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