Bipyridyl dihydrochloride inhibits tumor necrosis factor-α secretion by human keratinocytes on ultraviolet irradiation
Journal
Journal of the Formosan Medical Association
Journal Volume
95
Journal Issue
9
Pages
706-708
Date Issued
1996
Author(s)
Abstract
Paraquat manufacturers in Taiwan have been found to develop solar lentigo, actinic keratosis, as well as skin cancer in sun-exposed areas. Bipyridine has been found to be the responsible agent. At present, the mechanism for the pathogenesis of bipyridine-induced skin cancer is not known and it may be multifactorial. We investigated possible alterations in tumor necrosis factor (TNF)-α secretion in keratinocytes treated with 4,4'-bipyridyl dihydrochloride in vitro. Normal human keratinocytes were cultured and treated with bipyridine (10 μg/mL) or ultraviolet B (UVB) light (10 mJ/cm2), or with a combination of both. Bipyridine treatment alone resulted in a significant reduction in constitutive TNF-α secretion. Furthermore, in contrast to the finding in normal keratinocytes, UVB irradiation failed to promote TNF-α secretion in bipyridine-primed keratinocytes.
Subjects
4-4'-bipyridyl dihydrochloride; human; keratinocytes; tumor necrosis factor-α; ultraviolet light B
SDGs
Other Subjects
4,4' bipyridine; paraquat; tumor necrosis factor alpha; article; cytotoxicity; human; human cell; keratinocyte; pathogenesis; photodermatosis; protein expression; skin cancer; ultraviolet radiation; Humans; Keratinocytes; Male; Mitochondria; Pyridines; Tumor Necrosis Factor-alpha; Ultraviolet Rays
Type
journal article