https://scholars.lib.ntu.edu.tw/handle/123456789/517758
標題: | Bipyridyl dihydrochloride inhibits tumor necrosis factor-α secretion by human keratinocytes on ultraviolet irradiation | 作者: | SHIOU-HWA JEE TSEN-FANG TSAI Chen C.-C. Sun C.-C. Chang C.-H. Chang C.-C. |
關鍵字: | 4-4'-bipyridyl dihydrochloride; human; keratinocytes; tumor necrosis factor-α; ultraviolet light B | 公開日期: | 1996 | 卷: | 95 | 期: | 9 | 起(迄)頁: | 706-708 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Paraquat manufacturers in Taiwan have been found to develop solar lentigo, actinic keratosis, as well as skin cancer in sun-exposed areas. Bipyridine has been found to be the responsible agent. At present, the mechanism for the pathogenesis of bipyridine-induced skin cancer is not known and it may be multifactorial. We investigated possible alterations in tumor necrosis factor (TNF)-α secretion in keratinocytes treated with 4,4'-bipyridyl dihydrochloride in vitro. Normal human keratinocytes were cultured and treated with bipyridine (10 μg/mL) or ultraviolet B (UVB) light (10 mJ/cm2), or with a combination of both. Bipyridine treatment alone resulted in a significant reduction in constitutive TNF-α secretion. Furthermore, in contrast to the finding in normal keratinocytes, UVB irradiation failed to promote TNF-α secretion in bipyridine-primed keratinocytes. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030443535&partnerID=40&md5=2381e1afe78016746b0c5367349d86b6 https://scholars.lib.ntu.edu.tw/handle/123456789/517758 |
ISSN: | 0929-6646 | SDG/關鍵字: | 4,4' bipyridine; paraquat; tumor necrosis factor alpha; article; cytotoxicity; human; human cell; keratinocyte; pathogenesis; photodermatosis; protein expression; skin cancer; ultraviolet radiation; Humans; Keratinocytes; Male; Mitochondria; Pyridines; Tumor Necrosis Factor-alpha; Ultraviolet Rays |
顯示於: | 醫學系 |
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