Use of Insulin and Mortality from Breast Cancer among Taiwanese Women with Diabetes
Journal
Journal of Diabetes Research
Journal Volume
2015
Pages
678756
Date Issued
2015
Author(s)
Abstract
Background. To evaluate whether insulin use was predictive for mortality from breast cancer in Taiwanese women with diabetes mellitus. Methods. A total of 48,880 diabetic women were followed up to determine the mortality from breast cancer during 1995-2006. Cox models were used, considering the following independent variables: age, sex, diabetes type, diabetes duration, body mass index, smoking, insulin use, and area of residence. Insulin use was also considered for its duration of use at cutoffs of 3 years and 5 years. Results. Age was a significant predictor in all analyses. The multivariable-adjusted hazard ratio (95% confidence interval, P value) for insulin use without considering the duration of use was not statistically significant (1.339 [0.782-2.293, P = 0.2878 ]). Compared with nonusers, insulin users showed the following adjusted hazard ratios for insulin use <3 years, ? 3 years, <5 years, and ?5 years: 0.567 (0.179-1.791, P = 0.3333), 2.006 (1.102-3.653, P = 0.0228), 1.045 (0.505-2.162, P = 0.9048), and 1.899 (0.934-3.860, P = 0.0763). Conclusions. Insulin use (mainly human insulin) for ?3 years may be associated with a higher risk of breast cancer mortality. ? 2015 Chin-Hsiao Tseng.
SDGs
Other Subjects
insulin; antidiabetic agent; insulin; adult; aged; Article; breast cancer; cancer mortality; cancer risk; diabetes mellitus; female; follow up; hazard ratio; human; major clinical study; predictive value; priority journal; proportional hazards model; Taiwanese; treatment duration; body mass; breast tumor; cohort analysis; comorbidity; diabetes mellitus; middle aged; mortality; Overweight; retrospective study; risk factor; smoking; Taiwan; time factor; Adult; Aged; Body Mass Index; Breast Neoplasms; Cohort Studies; Comorbidity; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Insulin; Middle Aged; Overweight; Proportional Hazards Models; Retrospective Studies; Risk Factors; Smoking; Taiwan; Time Factors
Publisher
Hindawi Publishing Corporation
Type
journal article