https://scholars.lib.ntu.edu.tw/handle/123456789/496081
標題: | Use of Insulin and Mortality from Breast Cancer among Taiwanese Women with Diabetes | 作者: | CHIN-HSIAO TSENG | 公開日期: | 2015 | 出版社: | Hindawi Publishing Corporation | 卷: | 2015 | 起(迄)頁: | 678756 | 來源出版物: | Journal of Diabetes Research | 摘要: | Background. To evaluate whether insulin use was predictive for mortality from breast cancer in Taiwanese women with diabetes mellitus. Methods. A total of 48,880 diabetic women were followed up to determine the mortality from breast cancer during 1995-2006. Cox models were used, considering the following independent variables: age, sex, diabetes type, diabetes duration, body mass index, smoking, insulin use, and area of residence. Insulin use was also considered for its duration of use at cutoffs of 3 years and 5 years. Results. Age was a significant predictor in all analyses. The multivariable-adjusted hazard ratio (95% confidence interval, P value) for insulin use without considering the duration of use was not statistically significant (1.339 [0.782-2.293, P = 0.2878 ]). Compared with nonusers, insulin users showed the following adjusted hazard ratios for insulin use <3 years, ? 3 years, <5 years, and ?5 years: 0.567 (0.179-1.791, P = 0.3333), 2.006 (1.102-3.653, P = 0.0228), 1.045 (0.505-2.162, P = 0.9048), and 1.899 (0.934-3.860, P = 0.0763). Conclusions. Insulin use (mainly human insulin) for ?3 years may be associated with a higher risk of breast cancer mortality. ? 2015 Chin-Hsiao Tseng. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84932625676&doi=10.1155%2f2015%2f678756&partnerID=40&md5=4ba7d56fc34ac56b897f15e5e8ed5993 https://scholars.lib.ntu.edu.tw/handle/123456789/496081 |
ISSN: | 2314-6745 | DOI: | 10.1155/2015/678756 | SDG/關鍵字: | insulin; antidiabetic agent; insulin; adult; aged; Article; breast cancer; cancer mortality; cancer risk; diabetes mellitus; female; follow up; hazard ratio; human; major clinical study; predictive value; priority journal; proportional hazards model; Taiwanese; treatment duration; body mass; breast tumor; cohort analysis; comorbidity; diabetes mellitus; middle aged; mortality; Overweight; retrospective study; risk factor; smoking; Taiwan; time factor; Adult; Aged; Body Mass Index; Breast Neoplasms; Cohort Studies; Comorbidity; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Insulin; Middle Aged; Overweight; Proportional Hazards Models; Retrospective Studies; Risk Factors; Smoking; Taiwan; Time Factors |
顯示於: | 醫學系 |
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