Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine-Altering Variants
Journal
Journal of the American Heart Association
Journal Volume
12
Journal Issue
22
Pages
e032689
Date Issued
2023-11-21
Author(s)
Liao, Yi-Chu
Chung, Chih-Ping
Fann, Cathy S J
Chang, Chien-Ching
Lee, Yi-Chung
Abstract
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most prevalent monogenic cerebral small-vessel disease. Phenotype variability in CADASIL suggests the possible role of genetic modifiers. We aimed to investigate the contributions of the APOE genotype and Neurogenic locus notch homolog protein 3 (NOTCH3) variant position to cognitive impairment associated with CADASIL.
Subjects
APOE; CADASIL; NOTCH3; cerebral small‐vessel disease; vascular cognitive impairment
Type
journal article