https://scholars.lib.ntu.edu.tw/handle/123456789/637713
標題: | Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine-Altering Variants | 作者: | Cheng, Yu-Wen Liao, Yi-Chu CHIH-HAO CHEN Chung, Chih-Ping Fann, Cathy S J Chang, Chien-Ching Lee, Yi-Chung SUNG-CHUN TANG |
關鍵字: | APOE; CADASIL; NOTCH3; cerebral small‐vessel disease; vascular cognitive impairment | 公開日期: | 21-十一月-2023 | 卷: | 12 | 期: | 22 | 起(迄)頁: | e032689 | 來源出版物: | Journal of the American Heart Association | 摘要: | Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most prevalent monogenic cerebral small-vessel disease. Phenotype variability in CADASIL suggests the possible role of genetic modifiers. We aimed to investigate the contributions of the APOE genotype and Neurogenic locus notch homolog protein 3 (NOTCH3) variant position to cognitive impairment associated with CADASIL. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637713 | ISSN: | 2047-9980 | DOI: | 10.1161/JAHA.123.032689 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。