3′-hydroxypterostilbene potently alleviates obesity exacerbated colitis in mice
Journal
Journal of agricultural and food chemistry
Journal Volume
68
Journal Issue
19
Pages
5365-5374
Date Issued
2020
Author(s)
Abstract
Epidemiological surveys show that obesity and the western diet increase the risk of colitis. Studies have also confirmed that the high-fat-diet (HFD) promoted the deterioration of colitis-related indicators in mice. Compared with stilbenoids, the results showed that 3′-hydroxypterostilbene (HPSB) was found to be the most effective inhibitor for the antiadipogenesis and anti-inflammation. However, its role in ameliorating obesity-promoted colitis is still unknown. We intend to investigate the protective effect and related molecular mechanisms of HPSB on HFD promoted dextran sodium sulfate (DSS)-induced colitis in mice. The results indicate that colitis in the HFD+DSS group tends to be more apparent in the DSS-only group, while feeding 0.025% of HPSB at different stages can improve the colitis induced by HFD+DSS. HPSB significantly reduced the levels of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) induced by HFD+DSS in mice. Furthermore, the Western blotting revealed that the administration of HPSB significantly downregulated cyclooxygenase-2 (COX-2), plasmalemma vesicle-associated protein-1 (PV-1), and phospho-signal transducer and activator of transcription 3 (p-STAT3) expressions in HFD+DSS treated mice. Presented results reveal that HPSB is a novel functional agent capable of preventing HFD exacerbated colitis. ? 2020 American Chemical Society.
Subjects
3′-hydroxypterostilbene (hpsb); Chemoprevention; Colitis; Obesity
SDGs
Other Subjects
Cell membranes; Deterioration; Mammals; Nutrition; Proteins; Sodium sulfate; Sulfur compounds; Anti-inflammation; Chemoattractants; Cyclooxygenase 2; Different stages; Functional agents; Molecular mechanism; Protective effects; Signal transducers; Diseases; 3'-hydroxypterostilbene; antiinflammatory agent; dextran sulfate; interleukin 6; monocyte chemotactic protein 1; STAT3 protein; stilbene derivative; adverse event; animal; C57BL mouse; colitis; complication; disease model; genetics; human; immunology; lipid diet; male; mouse; obesity; Animals; Anti-Inflammatory Agents; Chemokine CCL2; Colitis; Dextran Sulfate; Diet, High-Fat; Disease Models, Animal; Humans; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Obesity; STAT3 Transcription Factor; Stilbenes
Type
journal article