https://scholars.lib.ntu.edu.tw/handle/123456789/566041
標題: | 3′-hydroxypterostilbene potently alleviates obesity exacerbated colitis in mice | 作者: | Lee, P.-S. Chiou, Y.-S. Nagabhushanam, K. Ho, C.-T. MIN-HSIUNG PAN |
關鍵字: | 3′-hydroxypterostilbene (hpsb); Chemoprevention; Colitis; Obesity | 公開日期: | 2020 | 卷: | 68 | 期: | 19 | 起(迄)頁: | 5365-5374 | 來源出版物: | Journal of agricultural and food chemistry | 摘要: | Epidemiological surveys show that obesity and the western diet increase the risk of colitis. Studies have also confirmed that the high-fat-diet (HFD) promoted the deterioration of colitis-related indicators in mice. Compared with stilbenoids, the results showed that 3′-hydroxypterostilbene (HPSB) was found to be the most effective inhibitor for the antiadipogenesis and anti-inflammation. However, its role in ameliorating obesity-promoted colitis is still unknown. We intend to investigate the protective effect and related molecular mechanisms of HPSB on HFD promoted dextran sodium sulfate (DSS)-induced colitis in mice. The results indicate that colitis in the HFD+DSS group tends to be more apparent in the DSS-only group, while feeding 0.025% of HPSB at different stages can improve the colitis induced by HFD+DSS. HPSB significantly reduced the levels of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) induced by HFD+DSS in mice. Furthermore, the Western blotting revealed that the administration of HPSB significantly downregulated cyclooxygenase-2 (COX-2), plasmalemma vesicle-associated protein-1 (PV-1), and phospho-signal transducer and activator of transcription 3 (p-STAT3) expressions in HFD+DSS treated mice. Presented results reveal that HPSB is a novel functional agent capable of preventing HFD exacerbated colitis. ? 2020 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85084626471&partnerID=40&md5=20a42bc0f24d23c5b18333407f85c5ff https://scholars.lib.ntu.edu.tw/handle/123456789/566041 |
DOI: | 10.1021/acs.jafc.0c01782 | SDG/關鍵字: | Cell membranes; Deterioration; Mammals; Nutrition; Proteins; Sodium sulfate; Sulfur compounds; Anti-inflammation; Chemoattractants; Cyclooxygenase 2; Different stages; Functional agents; Molecular mechanism; Protective effects; Signal transducers; Diseases; 3'-hydroxypterostilbene; antiinflammatory agent; dextran sulfate; interleukin 6; monocyte chemotactic protein 1; STAT3 protein; stilbene derivative; adverse event; animal; C57BL mouse; colitis; complication; disease model; genetics; human; immunology; lipid diet; male; mouse; obesity; Animals; Anti-Inflammatory Agents; Chemokine CCL2; Colitis; Dextran Sulfate; Diet, High-Fat; Disease Models, Animal; Humans; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Obesity; STAT3 Transcription Factor; Stilbenes |
顯示於: | 食品科技研究所 |
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