Machine learning-based longitudinal prediction for GJB2-related sensorineural hearing loss.
Journal
Computers in biology and medicine
Journal Volume
176
Start Page
Article number 108597
ISSN
1879-0534
Date Issued
2024-06
Author(s)
Chen, Pey-Yu
Yang, Ta-Wei
Tseng, Yi-Shan
Tsai, Cheng-Yu
Yeh, Chiung-Szu
Lee, Yen-Hui
Lin, Ting-Chun
Wu, Yu-Jen
Chiang, Yu-Ting
Hsu, Chuan-Jen
Chou, Chen-Fu
Abstract
Background: Recessive GJB2 variants, the most common genetic cause of hearing loss, may contribute to progressive sensorineural hearing loss (SNHL). The aim of this study is to build a realistic predictive model for GJB2-related SNHL using machine learning to enable personalized medical planning for timely intervention. Method: Patients with SNHL with confirmed biallelic GJB2 variants in a nationwide cohort between 2005 and 2022 were included. Different data preprocessing protocols and computational algorithms were combined to construct a prediction model. We randomly divided the dataset into training, validation, and test sets at a ratio of 72:8:20, and repeated this process ten times to obtain an average result. The performance of the models was evaluated using the mean absolute error (MAE), which refers to the discrepancy between the predicted and actual hearing thresholds. Results: We enrolled 449 patients with 2184 audiograms available for deep learning analysis. SNHL progression was identified in all models and was independent of age, sex, and genotype. The average hearing progression rate was 0.61 dB HL per year. The best MAE for linear regression, multilayer perceptron, long short-term memory, and attention model were 4.42, 4.38, 4.34, and 4.76 dB HL, respectively. The long short-term memory model performed best with an average MAE of 4.34 dB HL and acceptable accuracy for up to 4 years. Conclusions: We have developed a prognostic model that uses machine learning to approximate realistic hearing progression in GJB2-related SNHL, allowing for the design of individualized medical plans, such as recommending the optimal follow-up interval for this population.
Subjects
GJB2
Hereditary hearing loss
Long short-term memory model
Machine learning
Prediction model
Publisher
Elsevier Ltd
Type
journal article