In-vitro diagnosis of colon cancer using bio-functionalized magnetic nanoparticles
Journal
Proceedings of the ASME Design Engineering Technical Conference
Journal Volume
7
Pages
11-15
Date Issued
2011
Author(s)
Abstract
The popular bio-marker for colon cancer is carcinoembryonic antigen (CEA). By conjugating anti-CEA onto magnetic nanoparticles, CEA can be specially labeled and detected by measuring magnetic signals via immunomagnetic reduction (IMR). The low detection limit and detection range of IMR on CEA are investigated. The results are compared with those by using the existing assay, such as enzyme-linked immunosorbent assay (ELISA). It is evidenced that IMR has sensitivity much higher than that of ELISA. The low detection limit is below the normal level of CEA concentration of clinic practice and is suitable for early-stage in-vitro diagnosis for colon cancer. Furthermore, the dynamic range of detection for the CEA concentration using IMR extends well above the threshold of high risk level of colorectal carcinoma in current diagnosing practice. Therefore, IMR is also suitable in other stages diagnosis for colon cancer development. Copyright ? 2011 by ASME.
SDGs
Other Subjects
Carcinoembryonic antigen; Colon cancer; Colorectal carcinoma; Detection range; Dynamic range; Enzyme linked immunosorbent assay; High risk level; In-vitro; Low detection limit; Magnetic nanoparticles; Magnetic signals; Antigens; Design; Nanoparticles; Stress analysis; Diseases
Type
conference paper