An environmental friendly tapioca starch-alginate cultured scaffold as biomimetic muscle tissue
Journal
Polymers
Journal Volume
13
Journal Issue
17
Date Issued
2021
Author(s)
Abstract
Natural porous scaffolds have been studied and developed for decades in biomedical science in order to support cells with a simulated extracellular matrix in natural tissue as an ideal environment. Such three-dimensional scaffolds provide many degrees of freedom to modulate cell activity, such as porosity, pore size, mechanical strength, biodegradability, and biocompatibility. In this study, a porous, three-dimensional material of alginate incorporating tapioca starch was fabricated. A particular freeze-gelation method was applied to homogenously mix starch in the alginate, and the concentration was controllable. This pure natural composite porous scaffold was characterized physically and biologically. The synergistic functions, including biocompatibility, biodegradability, cell adhesion, and cell proliferation, were also investigated. A myogenic differentiation model further verified that the composite porous scaffold provided a suitable environment, supporting the differentiation effect in the myogenic process. The positive results demonstrated that this novel material has the potential to serve as a biomedical or clean meat appliance. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Subjects
Alginate
Composite scaffold
Myogenic differentiation
Starch
Biocompatibility
Biodegradability
Biomimetics
Cell adhesion
Cell proliferation
Cells
Degrees of freedom (mechanics)
Gelation
Muscle
Pore size
Biomedical science
Environmental-friendly
Extracellular matrices
Myogenic differentiations
Natural composites
Natural tissues
Novel materials
Three dimensional scaffold
Scaffolds (biology)
SDGs
Type
journal article