https://scholars.lib.ntu.edu.tw/handle/123456789/598230
標題: | An environmental friendly tapioca starch-alginate cultured scaffold as biomimetic muscle tissue | 作者: | Lin C.-W Wu P.-T Liu K.-T Fan Y.-J Yu J. JIASHING YU |
關鍵字: | Alginate;Composite scaffold;Myogenic differentiation;Starch;Biocompatibility;Biodegradability;Biomimetics;Cell adhesion;Cell proliferation;Cells;Degrees of freedom (mechanics);Gelation;Muscle;Pore size;Biomedical science;Environmental-friendly;Extracellular matrices;Myogenic differentiations;Natural composites;Natural tissues;Novel materials;Three dimensional scaffold;Scaffolds (biology) | 公開日期: | 2021 | 卷: | 13 | 期: | 17 | 來源出版物: | Polymers | 摘要: | Natural porous scaffolds have been studied and developed for decades in biomedical science in order to support cells with a simulated extracellular matrix in natural tissue as an ideal environment. Such three-dimensional scaffolds provide many degrees of freedom to modulate cell activity, such as porosity, pore size, mechanical strength, biodegradability, and biocompatibility. In this study, a porous, three-dimensional material of alginate incorporating tapioca starch was fabricated. A particular freeze-gelation method was applied to homogenously mix starch in the alginate, and the concentration was controllable. This pure natural composite porous scaffold was characterized physically and biologically. The synergistic functions, including biocompatibility, biodegradability, cell adhesion, and cell proliferation, were also investigated. A myogenic differentiation model further verified that the composite porous scaffold provided a suitable environment, supporting the differentiation effect in the myogenic process. The positive results demonstrated that this novel material has the potential to serve as a biomedical or clean meat appliance. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114046895&doi=10.3390%2fpolym13172882&partnerID=40&md5=d036f4b5a11b600062c127a6541c62cb https://scholars.lib.ntu.edu.tw/handle/123456789/598230 |
ISSN: | 20734360 | DOI: | 10.3390/polym13172882 |
顯示於: | 化學工程學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。