Inhibition of metastasis, angiogenesis, and tumor growth by Chinese herbal cocktail Tien-Hsien Liquid
Journal
BMC cancer
Journal Volume
10
Journal Issue
1
Date Issued
2010-04-30
Author(s)
Abstract
Advanced cancer is a multifactorial disease that demands treatments targeting multiple cellular pathways. Chinese herbal cocktail which contains various phytochemicals may target multiple dys-regulated pathways in cancer cells and thus may provide an alternative/complementary way to treat cancers. Previously we reported that the Chinese herbal cocktail Tien-Hsien Liguid (THL) can specifically induce apoptosis in various cancer cells and have immuno-modulating activity. In this study, we further evaluated the anti-metastatic, anti-angiogenic and anti-tumor activities of THL with a series of in vitro and in vivo experiments.
SDGs
Other Subjects
antineoplastic agent; gelatinase A; gelatinase B; herbaceous agent; hypoxia inducible factor 1alpha; mitogen activated protein kinase 1; mitogen activated protein kinase 3; tien hsien; unclassified drug; urokinase; vasculotropin A; antineoplastic agent; gelatinase A; gelatinase B; herbaceous agent; HIF1A protein, human; hypoxia inducible factor 1alpha; mitogen activated protein kinase 1; mitogen activated protein kinase 3; tien hsien liquid; tien-hsien liquid; urokinase; vasculotropin A; VEGFA protein, human; animal experiment; animal model; antiangiogenic activity; apoptosis; article; breast cancer; cancer cell; cancer inhibition; cell invasion; cell migration; controlled study; endothelium cell; female; human; human cell; lung metastasis; metastasis inhibition; mouse; nonhuman; protein expression; protein phosphorylation; animal; Bagg albino mouse; breast tumor; cancer invasion; cell motion; colon tumor; dose response; drug effect; drug screening; lung tumor; metabolism; metastasis; mouse mutant; neovascularization (pathology); nonobese diabetic mouse; pathology; time; tumor cell line; tumor volume; vascularization; Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelial Cells; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Neovascularization, Pathologic; Time Factors; Tumor Burden; Urokinase-Type Plasminogen Activator; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays
Publisher
BMC
Type
journal article