Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours
Journal
Gut
Journal Volume
71
Journal Issue
9
Pages
1843
Date Issued
2022-09
Author(s)
Huang, Hsi-Chien
Sung, Yun-Chieh
Li, Chung-Pin
Wan, Dehui
Chao, Po-Han
Tseng, Yu-Ting
Liao, Bo-Wen
Hsu, Fu-Fei
Huang, Chieh-Cheng
Chen, Yi-Ting
Liao, Yu-Hui
Hsieh, Hsin Tzu
Shih, Yu-Chuan
Liu, I-Ju
Wu, Han-Chung
Lu, Tsai-Te
JANE WANG
Chen, Yunching
Abstract
Stromal barriers, such as the abundant desmoplastic stroma that is characteristic of pancreatic ductal adenocarcinoma (PDAC), can block the delivery and decrease the tumour-penetrating ability of therapeutics such as tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), which can selectively induce cancer cell apoptosis. This study aimed to develop a TRAIL-based nanotherapy that not only eliminated the extracellular matrix barrier to increase TRAIL delivery into tumours but also blocked antiapoptotic mechanisms to overcome TRAIL resistance in PDAC.
Subjects
drug resistance; fibrosis; pancreatic cancer
SDGs
Publisher
BMJ PUBLISHING GROUP
Type
journal article