https://scholars.lib.ntu.edu.tw/handle/123456789/626808
標題: | Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours | 作者: | Huang, Hsi-Chien Sung, Yun-Chieh Li, Chung-Pin Wan, Dehui Chao, Po-Han Tseng, Yu-Ting Liao, Bo-Wen HUI-TENG CHENG Hsu, Fu-Fei Huang, Chieh-Cheng Chen, Yi-Ting Liao, Yu-Hui Hsieh, Hsin Tzu Shih, Yu-Chuan Liu, I-Ju Wu, Han-Chung Lu, Tsai-Te JANE WANG Chen, Yunching |
關鍵字: | drug resistance; fibrosis; pancreatic cancer | 公開日期: | 九月-2022 | 出版社: | BMJ PUBLISHING GROUP | 卷: | 71 | 期: | 9 | 起(迄)頁: | 1843 | 來源出版物: | Gut | 摘要: | Stromal barriers, such as the abundant desmoplastic stroma that is characteristic of pancreatic ductal adenocarcinoma (PDAC), can block the delivery and decrease the tumour-penetrating ability of therapeutics such as tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), which can selectively induce cancer cell apoptosis. This study aimed to develop a TRAIL-based nanotherapy that not only eliminated the extracellular matrix barrier to increase TRAIL delivery into tumours but also blocked antiapoptotic mechanisms to overcome TRAIL resistance in PDAC. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626808 | ISSN: | 0017-5749 | DOI: | 10.1136/gutjnl-2021-325180 |
顯示於: | 醫學系 |
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