An Asian patient with intraocular lymphoma treated by intravitreal methotrexate

Background: To demonstrate the efficacy of intravitreal methotrexate for treating intraocular lymphoma. Case: A 55-year-old immunocompetent Asian man was diagnosed with intraocular lymphoma. Observations: The patient was initially managed by intravenous administration of high-dose methotrexate. Because vitreous cells persisted after systemic chemotherapy, methotrexate was given intravitreally thereafter. There was only self-limited corneal epitheliopathy without major complications following intraocular injections. Ocular remission was sustained during a 21-month follow-up. Conclusion: Intravitreal methotrexate is an effective, repeatable, and safe treatment for intraocular lymphoma. ? Japanese Ophthalmological Society 2006.