Withanolide-based steroids from the cultured soft coral sinularia brassica
Journal
Journal of Natural Products
Journal Volume
76
Journal Issue
10
Pages
1902-1908
Date Issued
2013
Author(s)
Huang, C.-Y.
Liaw, C.-C.
Chen, B.-W.
Chen, P.-C.
Su, J.-H.
Sung, P.-J.
Chiang, M.Y.
Sheu, J.-H.
Abstract
Seven novel withanolides, sinubrasolides A-G (1-7), have been isolated from the cultured soft coral Sinularia brassica. The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of 1 was established by X-ray crystallographic analysis. The cytotoxicities of compounds 1-7 against a limited panel of cancer cell lines also were determined. ? 2013 The American Chemical Society and American Society of Pharmacognosy.
SDGs
Other Subjects
sinubrasolide A; sinubrasolide B; sinubrasolide C; sinubrasolide D; sinubrasolide E; sinubrasolide F; sinubrasolide G; unclassified drug; withanolide; article; cancer cell culture; carbon nuclear magnetic resonance; coral; drug acetylation; drug cytotoxicity; drug isolation; drug structure; nonhuman; proton nuclear magnetic resonance; Sinularia brassica; X ray crystallography; Animals; Anthozoa; Antineoplastic Agents; Crystallography, X-Ray; Drug Screening Assays, Antitumor; HT29 Cells; Humans; K562 Cells; Leukemia P388; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Withanolides
Type
journal article