Impaired T-lymphocyte proliferation function in biliary atresia patients with chronic cholestatic jaundice after a kasai operation
Journal
Pediatric Research
Journal Volume
60
Journal Issue
5
Pages
602-606
Date Issued
2006
Abstract
To investigate the association between chronic cholestatic jaundice, systemic immunity, and various infectious complications in patients with biliary atresia (BA), we performed a survey of the systemic immune function in 30 children with BA. Patients were divided into a jaundice group (total serum bilirubin ?2 mg/dL for >6 mo) and control group (total serum bilirubin <2 mg/dL for >6 mo) with comparable age. Patients were tested for serum immunoglobulin and complement levels, mitogen response, interleukin (IL)-4, IL-5, and interferon-gamma production after phytohemagglutinin (PHA) stimulation, blood cell and lymphocyte subpopulation counts, phagocytic function, and leukocyte adhesion complex. They were then followed prospectively for 6 mo, and severe infectious complications requiring hospitalization were recorded. Compared with jaundice-free patients, T-lymphocyte proliferation function, determined by PHA mitogen test was significantly lower (p = 0.02) in BA patients with chronic cholestatic jaundice after a Kasai operation. During the study period, patients with chronic cholestatic jaundice had a higher risk of severe infectious complications than their jaundice-free counterparts (risk ratio = 5.87; p = 0.001). In conclusion, BA patients with chronic cholestatic jaundice are associated with impairment of T-lymphocyte proliferation and increased incidence of severe infectious complications. ? International Pediatrics Research Foundation, Inc. 2006. All Rights Reserved.
SDGs
Other Subjects
immunoglobulin; interleukin 4; interleukin 5; mitogenic agent; phytohemagglutinin; adolescent; adult; article; bile duct atresia; blood level; cell proliferation; cellular immunity; clinical article; controlled study; disease association; female; human; humoral immunity; jaundice; male; portoenterostomy; preschool child; priority journal; school child; T lymphocyte; Adolescent; Adult; Biliary Atresia; Biliary Tract Surgical Procedures; Cell Proliferation; Child; Child, Preschool; Female; Humans; Immunity; Infant; Jaundice, Obstructive; Male; Postoperative Complications; T-Lymphocytes
Type
journal article