https://scholars.lib.ntu.edu.tw/handle/123456789/567958
標題: | Impaired T-lymphocyte proliferation function in biliary atresia patients with chronic cholestatic jaundice after a kasai operation | 作者: | JIA-FENG WU BOR-LUEN CHIANG HUEY-LING CHEN HONG-SHIEE LAI MEI-HWEI CHANG YEN-HSUAN NI |
公開日期: | 2006 | 卷: | 60 | 期: | 5 | 起(迄)頁: | 602-606 | 來源出版物: | Pediatric Research | 摘要: | To investigate the association between chronic cholestatic jaundice, systemic immunity, and various infectious complications in patients with biliary atresia (BA), we performed a survey of the systemic immune function in 30 children with BA. Patients were divided into a jaundice group (total serum bilirubin ?2 mg/dL for >6 mo) and control group (total serum bilirubin <2 mg/dL for >6 mo) with comparable age. Patients were tested for serum immunoglobulin and complement levels, mitogen response, interleukin (IL)-4, IL-5, and interferon-gamma production after phytohemagglutinin (PHA) stimulation, blood cell and lymphocyte subpopulation counts, phagocytic function, and leukocyte adhesion complex. They were then followed prospectively for 6 mo, and severe infectious complications requiring hospitalization were recorded. Compared with jaundice-free patients, T-lymphocyte proliferation function, determined by PHA mitogen test was significantly lower (p = 0.02) in BA patients with chronic cholestatic jaundice after a Kasai operation. During the study period, patients with chronic cholestatic jaundice had a higher risk of severe infectious complications than their jaundice-free counterparts (risk ratio = 5.87; p = 0.001). In conclusion, BA patients with chronic cholestatic jaundice are associated with impairment of T-lymphocyte proliferation and increased incidence of severe infectious complications. ? International Pediatrics Research Foundation, Inc. 2006. All Rights Reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750354325&doi=10.1203%2f01.PDR.0000242270.91973.ff&partnerID=40&md5=c9df51ec28537be6f05b19f4ebe31b0b https://scholars.lib.ntu.edu.tw/handle/123456789/567958 |
ISSN: | 0031-3998 | DOI: | 10.1203/01.PDR.0000242270.91973.ff | SDG/關鍵字: | immunoglobulin; interleukin 4; interleukin 5; mitogenic agent; phytohemagglutinin; adolescent; adult; article; bile duct atresia; blood level; cell proliferation; cellular immunity; clinical article; controlled study; disease association; female; human; humoral immunity; jaundice; male; portoenterostomy; preschool child; priority journal; school child; T lymphocyte; Adolescent; Adult; Biliary Atresia; Biliary Tract Surgical Procedures; Cell Proliferation; Child; Child, Preschool; Female; Humans; Immunity; Infant; Jaundice, Obstructive; Male; Postoperative Complications; T-Lymphocytes |
顯示於: | 醫學系 |
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