Genome-wide scan for circulating vascular adhesion protein-1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis
Journal
Journal of diabetes investigation
Journal Volume
9
Journal Issue
5
Pages
1067
Date Issued
2018-09
Author(s)
Hee, Siow-Wey
Lee, Wei-Jei
Lin, Ming-Wei
Hung, Yi-Jen
Lee, I-Te
Hung, Kuan-Yi
Assimes, Themistocles
Knowles, Joshua W
Nong, Jiun-Yi
Chiu, Yen-Feng
Abstract
Vascular adhesion protein-1 (VAP-1) is a membrane-bound amine oxidase highly expressed in mature adipocytes and released into the circulation. VAP-1 has been strongly implicated in several pathological processes, including diabetes, inflammation, hypertension, hepatic steatosis and renal diseases, and is an important disease marker and therapeutic target. Here, we aimed to identify the genetic loci for circulating VAP-1 levels.
Subjects
Linkage analysis; MACRO domain containing 2 gene; Vascular adhesion protein-1
SDGs
Publisher
WILEY
Type
journal article