Relapse of imported vivax malaria despite standard-dose primaquine therapy: An investigation with molecular genotyping analyses
Journal
Clinical Microbiology and Infection
Journal Volume
18
Journal Issue
7
Pages
E232-E234
Date Issued
2012
Author(s)
Abstract
Taiwan CDC investigated four cases of recurrent imported vivax malaria during 2003-2010. Molecular genotyping results and the lack of inter-episodes travel history indicated that two of the patients, who acquired vivax malaria in Indonesia and the Solomon Islands, respectively, suffered relapses after an interval of 3-4months, despite completing standard-dose primaquine therapy (30mg/day for 14days) for the first episode. Treatment with a higher dose of primaquine (60mg/day for 14days) prevented further relapse in both patients. This finding calls for further monitoring of the therapeutic efficacy of primaquine in treating Plasmodium vivax acquired in southeast Asia and Oceania. ? 2012 The Authors. Clinical Microbiology and Infection ? 2012 European Society of Clinical Microbiology and Infectious Diseases.
SDGs
Other Subjects
primaquine; adult; article; case report; drug efficacy; drug megadose; female; genetic analysis; human; Indonesia; malaria control; male; molecular genetics; Pacific islands; Plasmodium vivax malaria; priority journal; relapse; Solomon Islands; Southeast Asia; Taiwan; Plasmodium vivax
Publisher
Blackwell Publishing Ltd
Type
journal article