BCAS2, a protein enriched in advanced prostate cancer, interacts with NBS1 to enhance DNA double-strand break repair
Journal
British journal of cancer
Date Issued
2020-09-23
Author(s)
Abstract
Breast cancer amplified sequence 2 (BCAS2) plays crucial roles in pre-mRNA splicing and androgen receptor transcription. Previous studies suggested that BCAS2 is involved in double-strand breaks (DSB); therefore, we aimed to characterise its mechanism and role in prostate cancer (PCa).
SDGs
Other Subjects
beta catenin; breast cancer amplified sequence 2; glutathione transferase; nuclear protein; unclassified drug; BCAS2 protein, human; cell cycle protein; DNA; DNA ligase; NBN protein, human; nuclear protein; tumor protein; amino terminal sequence; apoptosis; Article; carboxy terminal sequence; controlled study; DNA damage; double strand break repair; Drosophila; flow cytometry; gene; homologous recombination; human; human cell; human tissue; immunofluorescence microscopy; immunohistochemistry; immunoprecipitation; in vitro study; in vivo study; male; nbs1 gene; nonhomologous end joining repair; nonhuman; priority journal; prostate cancer; tumor growth; upregulation; Western blotting; animal; cancer grading; DNA end joining repair; double stranded DNA break; genetics; metabolism; pathology; physiology; prostate tumor; radiation response; Animals; Apoptosis; Cell Cycle Proteins; DNA; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA Repair Enzymes; Drosophila; Humans; Male; Neoplasm Grading; Neoplasm Proteins; Nuclear Proteins; Prostatic Neoplasms
Publisher
SPRINGERNATURE
Type
journal article