https://scholars.lib.ntu.edu.tw/handle/123456789/522091
標題: | BCAS2, a protein enriched in advanced prostate cancer, interacts with NBS1 to enhance DNA double-strand break repair | 作者: | Wang, Li-Po Chen, Tzu-Yu Kang, Chun-Kai HSIANG-PO HUANG SHOW-LI CHEN |
公開日期: | 23-九月-2020 | 出版社: | SPRINGERNATURE | 來源出版物: | British journal of cancer | 摘要: | Breast cancer amplified sequence 2 (BCAS2) plays crucial roles in pre-mRNA splicing and androgen receptor transcription. Previous studies suggested that BCAS2 is involved in double-strand breaks (DSB); therefore, we aimed to characterise its mechanism and role in prostate cancer (PCa). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/522091 | ISSN: | 0007-0920 1532-1827 |
DOI: | 10.1038/s41416-020-01086-y | SDG/關鍵字: | beta catenin; breast cancer amplified sequence 2; glutathione transferase; nuclear protein; unclassified drug; BCAS2 protein, human; cell cycle protein; DNA; DNA ligase; NBN protein, human; nuclear protein; tumor protein; amino terminal sequence; apoptosis; Article; carboxy terminal sequence; controlled study; DNA damage; double strand break repair; Drosophila; flow cytometry; gene; homologous recombination; human; human cell; human tissue; immunofluorescence microscopy; immunohistochemistry; immunoprecipitation; in vitro study; in vivo study; male; nbs1 gene; nonhomologous end joining repair; nonhuman; priority journal; prostate cancer; tumor growth; upregulation; Western blotting; animal; cancer grading; DNA end joining repair; double stranded DNA break; genetics; metabolism; pathology; physiology; prostate tumor; radiation response; Animals; Apoptosis; Cell Cycle Proteins; DNA; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA Repair Enzymes; Drosophila; Humans; Male; Neoplasm Grading; Neoplasm Proteins; Nuclear Proteins; Prostatic Neoplasms |
顯示於: | 基因體暨蛋白體醫學研究所 |
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