Repurposing the tyrosine kinase inhibitor nilotinib for use against intracellular multidrug-resistant Salmonella Typhimurium
Journal
Journal of microbiology, immunology, and infection
Date Issued
2023-01-17
Author(s)
Abstract
The increasing incidence of infections caused by multidrug-resistant Salmonella enterica has become a serious threat to global public health. Here, we found that the tyrosine kinase inhibitor nilotinib exhibits antibacterial activity against intracellular S. enterica serovar Typhimurium in RAW264.7 macrophages. Thus, we aimed to pharmacologically exploit the anti-intracellular Salmonella activity of nilotinib and to elucidate its mechanism of action.
Subjects
AICAR; AMPK; Autophagy; High-content analysis; Metformin
SDGs
Type
journal article