https://scholars.lib.ntu.edu.tw/handle/123456789/627522
標題: | Repurposing the tyrosine kinase inhibitor nilotinib for use against intracellular multidrug-resistant Salmonella Typhimurium | 作者: | Chou, Shih-Hsiu Wan, Tsai-Wen Shiau, Chung-Wai Chen, Ling-Han Lin, Hsueh-Chun HAO-CHIEH CHIU |
關鍵字: | AICAR; AMPK; Autophagy; High-content analysis; Metformin | 公開日期: | 17-一月-2023 | 來源出版物: | Journal of microbiology, immunology, and infection | 摘要: | The increasing incidence of infections caused by multidrug-resistant Salmonella enterica has become a serious threat to global public health. Here, we found that the tyrosine kinase inhibitor nilotinib exhibits antibacterial activity against intracellular S. enterica serovar Typhimurium in RAW264.7 macrophages. Thus, we aimed to pharmacologically exploit the anti-intracellular Salmonella activity of nilotinib and to elucidate its mechanism of action. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627522 | ISSN: | 16841182 | DOI: | 10.1016/j.jmii.2023.01.005 |
顯示於: | 醫學檢驗暨生物技術學系 |
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