Monitoring of T790M in plasma ctDNA of advanced EGFR-mutant NSCLC patients on first- or second-generation tyrosine kinase inhibitors
Journal
BMC cancer
Journal Volume
23
Journal Issue
1
Date Issued
2023-03-13
Author(s)
Lin, Chih-An
Su, Te-Jen
Abstract
The T790M mutation is the major resistance mechanism to first- and second-generation TKIs in EGFR-mutant NSCLC. This study aimed to investigate the utility of droplet digital PCR (ddPCR) for detection of T790M in plasma circulating tumor DNA (ctDNA), and explore its impact on prognosis.
Subjects
Droplet digital polymerase chain reaction; EGFR mutation; Lung cancer; Osimertinib; Tyrosine kinase inhibitor
SDGs
Publisher
BMC
Type
journal article