Intracellular pH-responsive mesoporous silica nanoparticles for the controlled release of anticancer chemotherapeutics
Journal
Angewandte Chemie - International Edition
Journal Volume
49
Journal Issue
44
Pages
8214-8219
Date Issued
2010
Author(s)
Abstract
Cut here to cure: Doxorubicin attached to pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH-sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death. ? 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Subjects
Antitumor agents; Apoptosis; Controlled release; Doxorubicin; Mesoporous silica
SDGs
Other Subjects
Anti-tumor agents; Apoptosis; Controlled release; Doxorubicin; Mesoporous Silica; Cell death; Mesoporous materials; Nanoparticles; Silica; antineoplastic agent; drug carrier; nanoparticle; silicon dioxide; article; cell line; chemistry; confocal microscopy; human; infrared spectroscopy; pH; spectrofluorometry; transmission electron microscopy; Antineoplastic Agents; Cell Line; Drug Carriers; Humans; Hydrogen-Ion Concentration; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles; Silicon Dioxide; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared
Type
journal article