Biomimetic PDMS-gum Arabic hybrid biopolymer adhesive for drug delivery
Journal
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Journal Volume
1
Pages
544-546
Date Issued
2018
Author(s)
Wang P.-H
Abstract
We propose a hybrid adhesive that consist of an array of microscale pillars to mimic the sticky mucilage, secreted by Sundew plant to catch preys. The micro-pillars are made of PDMS and Gum-Arabic, a synthetic biopolymer with complex and branched structures, to confer adhesive property, despite in wet condition. Further, Kanamycin A - an antibiotic for treating severe bacterial infections - is employed in our adhesives. The adhesive with hybrid biopolymer and micro-pillar shows higher adhesion forces, compared to the samples made of PDMS-only or flat surfaces. It thus holds the potential being a sticker and better biocompatible adhesive for transdermal drug delivery. Copyright? (2018) by Chemical and Biological Microsystems Society.All rights reserved.
Subjects
Biocompatibility; Biomimetics; Biomolecules; Biopolymers; Controlled drug delivery; Microchannels; Targeted drug delivery; Adhesion forces; Adhesive properties; Bacterial infections; Branched structures; Flat surfaces; Hybrid adhesives; Transdermal drug delivery; Wet conditions; Adhesives
Type
conference paper