Cembrane derivatives from the soft corals, Sinularia gaweli and Sinularia flexibilis
Journal
Marine Drugs
Journal Volume
11
Journal Issue
6
Pages
2154-2167
Date Issued
2013
Author(s)
Hu L.-C.
Yen W.-H.
Su J.-H.
Chiang M.Y.-N.
Wen Z.-H.
Chen W.-F.
Chang Y.-W.
Chen Y.-H.
Wang W.-H.
Wu Y.-C.
Sung P.-J.
Abstract
A new norcembranoidal diterpene, 1-epi-sinulanorcembranolide A (1), and a new cembranoidal diterpene, flexibilin D (2), were isolated from the soft corals, Sinularia gaweli and Sinularia flexibilis, respectively. The structures of new metabolites 1 and 2 were elucidated by spectroscopic methods, and compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. In addition, S. flexibilis yielded a known cembrane, 5-dehydrosinulariolide (3); the structure, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. ? 2013 by the authors; licensee MDPI.
Subjects
Anti-inflammatory activity
Cembrane
Norcembrane
Sinularia flexibilis
Sinularia gaweli
X-ray
Type
journal article
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