|Title:||Cembrane derivatives from the soft corals, Sinularia gaweli and Sinularia flexibilis||Authors:||Hu L.-C.
|Keywords:||Anti-inflammatory activity;Cembrane;Norcembrane;Sinularia flexibilis;Sinularia gaweli;X-ray||Issue Date:||2013||Journal Volume:||11||Journal Issue:||6||Start page/Pages:||2154-2167||Source:||Marine Drugs||Abstract:||
A new norcembranoidal diterpene, 1-epi-sinulanorcembranolide A (1), and a new cembranoidal diterpene, flexibilin D (2), were isolated from the soft corals, Sinularia gaweli and Sinularia flexibilis, respectively. The structures of new metabolites 1 and 2 were elucidated by spectroscopic methods, and compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. In addition, S. flexibilis yielded a known cembrane, 5-dehydrosinulariolide (3); the structure, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. ? 2013 by the authors; licensee MDPI.
|Appears in Collections:||食品科技研究所|
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